Discovery of pyrano[2,3-d]pyrimidine-2,4-dione derivatives as novel PARP-1 inhibitors: design, synthesis and antitumor activity

Poly(ADP-ribose) polymerases-1 (PARP-1) are involved in DNA repair damage and so PARP-1 inhibitors have been used as potentiators in combination with DNA damaging cytotoxic agents to compromise the cancer cell DNA repair mechanism, resulting in genomic dysfunction and cell death. In this study, we r...

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Detalles Bibliográficos
Autores principales: Abd El-sattar, Nour E. A., Badawy, Eman H. K., Elrazaz, Eman Z., Ismail, Nasser S. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8694318/
https://www.ncbi.nlm.nih.gov/pubmed/35424391
http://dx.doi.org/10.1039/d0ra10321g

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8694318/
https://www.ncbi.nlm.nih.gov/pubmed/35424391
http://dx.doi.org/10.1039/d0ra10321g

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