Impact of Maximizing Css/MIC Ratio on Efficacy of Continuous Infusion Meropenem Against Documented Gram-Negative Infections in Critically Ill Patients and Population Pharmacokinetic/Pharmacodynamic Analysis to Support Treatment Optimization

Introduction: optimal treatment of Gram-negative infections in critically ill patients is challenged by changing pathophysiological conditions, reduced antimicrobial susceptibility and limited therapeutic options. The aim of this study was to assess the impact of maximizing Css/MIC ratio on efficacy...

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Detalles Bibliográficos
Autores principales: Cojutti, Pier Giorgio, Gatti, Milo, Rinaldi, Matteo, Tonetti, Tommaso, Laici, Cristiana, Mega, Chiara, Siniscalchi, Antonio, Giannella, Maddalena, Viale, Pierluigi, Pea, Federico
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8694396/
https://www.ncbi.nlm.nih.gov/pubmed/34955851
http://dx.doi.org/10.3389/fphar.2021.781892

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8694396/
https://www.ncbi.nlm.nih.gov/pubmed/34955851
http://dx.doi.org/10.3389/fphar.2021.781892

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