Sex- and Mutation-Specific p53 Gain-of-Function Activity in Gliomagenesis

In cancer, missense mutations in the DNA-binding domain of TP53 are common. They abrogate canonical p53 activity and frequently confer gain-of-oncogenic function (GOF) through localization of transcriptionally active mutant p53 to noncanonical genes. We found that several recurring p53 mutations exh...

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Detalles Bibliográficos
Autores principales: Rockwell, Nathan C., Yang, Wei, Warrington, Nicole M., Staller, Max V., Griffith, Malachi, Griffith, Obi L., Gurnett, Christina A., Cohen, Barak A., Baldridge, Dustin, Rubin, Joshua B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8694557/
https://www.ncbi.nlm.nih.gov/pubmed/34957471
http://dx.doi.org/10.1158/2767-9764.CRC-21-0026

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8694557/
https://www.ncbi.nlm.nih.gov/pubmed/34957471
http://dx.doi.org/10.1158/2767-9764.CRC-21-0026

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