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Sex- and Mutation-Specific p53 Gain-of-Function Activity in Gliomagenesis
In cancer, missense mutations in the DNA-binding domain of TP53 are common. They abrogate canonical p53 activity and frequently confer gain-of-oncogenic function (GOF) through localization of transcriptionally active mutant p53 to noncanonical genes. We found that several recurring p53 mutations exh...
| Autores principales: | , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Association for Cancer Research
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8694557/ https://www.ncbi.nlm.nih.gov/pubmed/34957471 http://dx.doi.org/10.1158/2767-9764.CRC-21-0026 |