Is amyloid fibrillation related to 3D domain swapping for the C-terminal domain of SARS-CoV main protease?

The C-terminal domain of SARS-CoV main protease (M(pro)-C) can form 3D domain-swapped dimer by exchanging the α(1)-helices fully buried inside the protein hydrophobic core, under non-denaturing conditions. Here, we report that M(pro)-C can also form amyloid fibrils under the 3D domain-swappable cond...

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Detalles Bibliográficos
Autores principales: Yuan, Zhiliang, Qu, Zhi, Duan, Bo, Wang, Tianyi, Xu, Jiajun, Xia, Bin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V. 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8694786/
https://www.ncbi.nlm.nih.gov/pubmed/34953805
http://dx.doi.org/10.1016/j.ijbiomac.2021.12.072

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8694786/
https://www.ncbi.nlm.nih.gov/pubmed/34953805
http://dx.doi.org/10.1016/j.ijbiomac.2021.12.072

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