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Is amyloid fibrillation related to 3D domain swapping for the C-terminal domain of SARS-CoV main protease?
The C-terminal domain of SARS-CoV main protease (M(pro)-C) can form 3D domain-swapped dimer by exchanging the α(1)-helices fully buried inside the protein hydrophobic core, under non-denaturing conditions. Here, we report that M(pro)-C can also form amyloid fibrils under the 3D domain-swappable cond...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier B.V.
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8694786/ https://www.ncbi.nlm.nih.gov/pubmed/34953805 http://dx.doi.org/10.1016/j.ijbiomac.2021.12.072 |