Synthesis and biological evaluation of fluorinated 3,4-dihydroquinolin-2(1H)-ones and 2-oxindoles for anti-hepatic fibrosis

(Z)-4-(Iodomethylene)-3-(2,2,2-trifluoroethyl)-3,4-dihydroquinolin-2(1H)-ones and fluorinated 3,3-disubstituted 2-oxindoles are synthesized and evaluated for anti-hepatic fibrosis. CCK-8 assay indicates that most of the compounds have no obvious cytotoxicity on the human hepatic stellate cells (HSC)...

Descripción completa

Detalles Bibliográficos
Autores principales: Li, Man, He, Fu-Sheng, Ji, Long-Shan, Gao, Ya-Ting, Zhang, Xin, Yu, Zhuo, Fang, Miao, Wu, Jie, Gao, Yue-Qiu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8694865/
https://www.ncbi.nlm.nih.gov/pubmed/35423132
http://dx.doi.org/10.1039/d0ra09430g

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8694865/
https://www.ncbi.nlm.nih.gov/pubmed/35423132
http://dx.doi.org/10.1039/d0ra09430g

Ejemplares similares