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Synthesis and biological evaluation of fluorinated 3,4-dihydroquinolin-2(1H)-ones and 2-oxindoles for anti-hepatic fibrosis

(Z)-4-(Iodomethylene)-3-(2,2,2-trifluoroethyl)-3,4-dihydroquinolin-2(1H)-ones and fluorinated 3,3-disubstituted 2-oxindoles are synthesized and evaluated for anti-hepatic fibrosis. CCK-8 assay indicates that most of the compounds have no obvious cytotoxicity on the human hepatic stellate cells (HSC)...

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Detalles Bibliográficos
Autores principales:	Li, Man, He, Fu-Sheng, Ji, Long-Shan, Gao, Ya-Ting, Zhang, Xin, Yu, Zhuo, Fang, Miao, Wu, Jie, Gao, Yue-Qiu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Royal Society of Chemistry 2021
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8694865/ https://www.ncbi.nlm.nih.gov/pubmed/35423132 http://dx.doi.org/10.1039/d0ra09430g

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