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Improved herbicide discovery using physico-chemical rules refined by antimalarial library screening

Herbicides have physico-chemical properties not unlike orally-delivered human drugs, but are known to diverge in their limits for proton donors, partition coefficients and molecular weight. To further refine rules specific for herbicides, we exploited the close evolutionary relationship between Plas...

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Detalles Bibliográficos
Autores principales: Sukhoverkov, Kirill V., Corral, Maxime G., Leroux, Julie, Haywood, Joel, Johnen, Philipp, Newton, Trevor, Stubbs, Keith A., Mylne, Joshua S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8695207/
https://www.ncbi.nlm.nih.gov/pubmed/35423398
http://dx.doi.org/10.1039/d1ra00914a