Ligand-based pharmacophore modeling, virtual screening and biological evaluation to identify novel TGR5 agonists

Takeda G-protein-coupled receptor 5 (TGR5) is emerging as an important and promising target for the development of anti-diabetic drugs. To understand the structural characteristics of TGR5 agonists, the common feature pharmacophore models were generated and molecular docking was performed. The ligan...

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Detalles Bibliográficos
Autores principales: Zhao, Shizhen, Li, Xinping, Peng, Wenjing, Wang, Le, Ye, Wenling, Zhao, Yang, Yin, Wenbo, Chen, Wei-Dong, Li, Weiguo, Wang, Yan-Dong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8695346/
https://www.ncbi.nlm.nih.gov/pubmed/35423434
http://dx.doi.org/10.1039/d0ra10168k

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8695346/
https://www.ncbi.nlm.nih.gov/pubmed/35423434
http://dx.doi.org/10.1039/d0ra10168k

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