Cargando…
Total synthesis of landomycins Q and R and related core structures for exploration of the cytotoxicity and antibacterial properties
Herein, we report the total synthesis of landomycins Q and R as well as the aglycone core, namely anhydrolandomycinone and a related core analogue. The synthesis features an acetate-assisted arylation method for construction of the hindered B-ring in the core component and a one-pot aromatization–de...
Autores principales: | Lai, Yao-Hsuan, Mondal, Soumik, Su, Hsin-Tzu, Huang, Sheng-Cih, Wu, Mine-Hsine, Huang, I.-Wen, Yang Lauderdale, Tsai-Ling, Song, Jen-Shin, Shia, Kak-Shan, Mong, Kwok-Kong Tony |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Royal Society of Chemistry
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8695357/ https://www.ncbi.nlm.nih.gov/pubmed/35423459 http://dx.doi.org/10.1039/d1ra01088c |
Ejemplares similares
-
11-Deoxylandomycinone and landomycins X-Z, new cytotoxic angucyclin(on)es from a Streptomyces cyanogenus K62 mutant strain
por: Shaaban, Khaled A., et al.
Publicado: (2010) -
Landomycins as glutathione-depleting agents and natural fluorescent probes for cellular Michael adduct-dependent quinone metabolism
por: Terenzi, Alessio, et al.
Publicado: (2021) -
Cytotoxic, Antibacterial, and Antioxidant Activities of the Leaf Extract of Sinningia bullata
por: Chen, Pin-Jui, et al.
Publicado: (2023) -
Development of a Cross‐Conjugated Vinylogous [4+2] Anionic Annulation and Application to the Total Synthesis of Natural Antibiotic (±)‐ABX
por: Huang, Jing‐Kai, et al.
Publicado: (2020) -
Anionic Diels–Alder Chemistry of Cyclic Sodium
Dien-1-olates Delivering Highly Stereoselective and Functionalized
Polycyclic Adducts
por: Huang, Jing-Kai, et al.
Publicado: (2021)