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The active site region plays a critical role in Na(+) binding to thrombin

The catalytic activity of thrombin and other enzymes of the blood coagulation and complement cascades is enhanced significantly by binding of Na(+) to a site >15 Å away from the catalytic residue S195, buried within the 180 and 220 loops that also contribute to the primary specificity of the enzy...

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Detalles Bibliográficos
Autores principales: Pelc, Leslie A., Koester, Sarah K., Kukla, Cassandra R., Chen, Zhiwei, Di Cera, Enrico
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8695361/
https://www.ncbi.nlm.nih.gov/pubmed/34861239
http://dx.doi.org/10.1016/j.jbc.2021.101458