Novel Small Molecules Capable of Blocking mtRAS-Signaling Pathway

RAS mutants are involved in approximately 30% of all human cancers and have been regarded as undruggable targets owing to relatively smooth protein surface and obscure binding pockets. In our previous study, we have demonstrated that GNF-7, a multi-targeted kinase inhibitor, possesses potent anti-pr...

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Detalles Bibliográficos
Autores principales: Kim, Namkyoung, Shin, Injae, Kim, Younghoon, Jeon, Eunhye, Lee, Jiwon, Lee, Chaeyoung, Nam, Yunju, Lee, Sumin, Ju, Eunhye, Kim, Chan, Son, Woolim, Ryu, SeongShick, Ko, Minjoo, Sim, Taebo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8695447/
https://www.ncbi.nlm.nih.gov/pubmed/34956887
http://dx.doi.org/10.3389/fonc.2021.768022

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8695447/
https://www.ncbi.nlm.nih.gov/pubmed/34956887
http://dx.doi.org/10.3389/fonc.2021.768022

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