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Gradual, but Not Sudden, Dose-Dependent Increase of ONJ Risk With Bisphosphonate Exposure: A Nationwide Cohort Study in Women With Osteoporosis

BACKGROUND: A causal relationship of bisphosphonate (BP) exposure with osteonecrosis of the jaw (ONJ) has been reported; however, a definite dose-dependent risk remains to be elucidated beyond current vague recommendations of 4-year oral BP for ONJ risk increase. OBJECTIVE: To identify the effect of...

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Detalles Bibliográficos
Autores principales: Park, Jung-Hyun, Kwoen, Min-Jeong, Lee, Jae-Ryun, Kim, Keun-Suh, Lee, Hyo-Jung, Kim, Jin-Woo, Lee, Hyejin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8695600/
https://www.ncbi.nlm.nih.gov/pubmed/34956086
http://dx.doi.org/10.3389/fendo.2021.774820