Discovery and characterization of naturally occurring potent inhibitors of catechol-O-methyltransferase from herbal medicines

Human catechol-O-methyltransferase (hCOMT) is considered a therapeutic target due to its crucial roles in the metabolic inactivation of endogenous neurotransmitters and xenobiotic drugs. There are nevertheless few safe and effective COMT inhibitors and there lacks a diversity in structure. To discov...

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Detalles Bibliográficos
Autores principales: Zhao, Dong-Fang, Fan, Yu-Fan, Wang, Fang-Yuan, Hou, Fan-Bin, Gonzalez, Frank J., Li, Shi-Yang, Wang, Ping, Xia, Yang-Liu, Ge, Guang-Bo, Yang, Ling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8695704/
https://www.ncbi.nlm.nih.gov/pubmed/35423513
http://dx.doi.org/10.1039/d0ra10425f

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8695704/
https://www.ncbi.nlm.nih.gov/pubmed/35423513
http://dx.doi.org/10.1039/d0ra10425f

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