Cargando…

Public Immunity: Evolutionary Spandrels for Pathway-Amplifying Protective Antibodies

Humoral immunity is seeded by affinity between the B cell receptor (BCR) and cognate antigen. While the BCR is a chimeric display of diverse antigen engagement solutions, we discuss its functional activity as an ‘innate-like’ immune receptor, wherein genetically hardwired antigen complementarity can...

Descripción completa

Detalles Bibliográficos
Autores principales: Sangesland, Maya, Lingwood, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8696009/
https://www.ncbi.nlm.nih.gov/pubmed/34956170
http://dx.doi.org/10.3389/fimmu.2021.708882
_version_ 1784619709639950336
author Sangesland, Maya
Lingwood, Daniel
author_facet Sangesland, Maya
Lingwood, Daniel
author_sort Sangesland, Maya
collection PubMed
description Humoral immunity is seeded by affinity between the B cell receptor (BCR) and cognate antigen. While the BCR is a chimeric display of diverse antigen engagement solutions, we discuss its functional activity as an ‘innate-like’ immune receptor, wherein genetically hardwired antigen complementarity can serve as reproducible templates for pathway-amplifying otherwise immunologically recessive antibody responses. We propose that the capacity for germline reactivity to new antigen emerged as a set of evolutionary spandrels or coupled traits, which can now be exploited by rational vaccine design to focus humoral immunity upon conventionally immune-subdominant antibody targets. Accordingly, we suggest that evolutionary spandrels account for the necessary but unanticipated antigen reactivity of the germline antibody repertoire.
format Online
Article
Text
id pubmed-8696009
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-86960092021-12-24 Public Immunity: Evolutionary Spandrels for Pathway-Amplifying Protective Antibodies Sangesland, Maya Lingwood, Daniel Front Immunol Immunology Humoral immunity is seeded by affinity between the B cell receptor (BCR) and cognate antigen. While the BCR is a chimeric display of diverse antigen engagement solutions, we discuss its functional activity as an ‘innate-like’ immune receptor, wherein genetically hardwired antigen complementarity can serve as reproducible templates for pathway-amplifying otherwise immunologically recessive antibody responses. We propose that the capacity for germline reactivity to new antigen emerged as a set of evolutionary spandrels or coupled traits, which can now be exploited by rational vaccine design to focus humoral immunity upon conventionally immune-subdominant antibody targets. Accordingly, we suggest that evolutionary spandrels account for the necessary but unanticipated antigen reactivity of the germline antibody repertoire. Frontiers Media S.A. 2021-12-09 /pmc/articles/PMC8696009/ /pubmed/34956170 http://dx.doi.org/10.3389/fimmu.2021.708882 Text en Copyright © 2021 Sangesland and Lingwood https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Sangesland, Maya
Lingwood, Daniel
Public Immunity: Evolutionary Spandrels for Pathway-Amplifying Protective Antibodies
title Public Immunity: Evolutionary Spandrels for Pathway-Amplifying Protective Antibodies
title_full Public Immunity: Evolutionary Spandrels for Pathway-Amplifying Protective Antibodies
title_fullStr Public Immunity: Evolutionary Spandrels for Pathway-Amplifying Protective Antibodies
title_full_unstemmed Public Immunity: Evolutionary Spandrels for Pathway-Amplifying Protective Antibodies
title_short Public Immunity: Evolutionary Spandrels for Pathway-Amplifying Protective Antibodies
title_sort public immunity: evolutionary spandrels for pathway-amplifying protective antibodies
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8696009/
https://www.ncbi.nlm.nih.gov/pubmed/34956170
http://dx.doi.org/10.3389/fimmu.2021.708882
work_keys_str_mv AT sangeslandmaya publicimmunityevolutionaryspandrelsforpathwayamplifyingprotectiveantibodies
AT lingwooddaniel publicimmunityevolutionaryspandrelsforpathwayamplifyingprotectiveantibodies