Structure-based design of 5′-substituted 1,2,3-triazolylated oseltamivir derivatives as potent influenza neuraminidase inhibitors

Resistant viruses containing mutant neuraminidases (NAs) with diminished drug affinity continue to emerge, and new anti-influenza agents are urgently required. Several potent inhibitors targeting the hydrophobic 150-cavity of viral NAs have been developed by modifying the antiviral drugs, oseltamivi...

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Detalles Bibliográficos
Autores principales: Wang, Pengfei, Oladejo, Babayemi O., Li, Chenning, Fu, Lifeng, Zhang, Shanshan, Qi, Jianxun, Lv, Xun, Li, Xuebing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8696196/
https://www.ncbi.nlm.nih.gov/pubmed/35423449
http://dx.doi.org/10.1039/d1ra00472g

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8696196/
https://www.ncbi.nlm.nih.gov/pubmed/35423449
http://dx.doi.org/10.1039/d1ra00472g

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