Isolation, semi-synthesis, docking-based prediction, and bioassay-based activity of Dolichandrone spathacea iridoids: new catalpol derivatives as glucosidase inhibitors

Dolichandrone spathacea iridoids are promising anti-diabetic inhibitors towards α-glucosidase protein (PDB-3W37) and oligo-1,6-glucosidase protein (PDB-3AJ7). Five catalpol iridoids (1, 2, 10, 13, 14) were isolated from mangrove plant D. spathacea, and their derivatives (3, 4, 5, 6, 7, 8, 9, 11, 12,...

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Detalles Bibliográficos
Autores principales: Phuong Thao, Tran Thi, Bui, Thanh Q., Quy, Phan Tu, Bao, Nguyen Chi, Van Loc, Tran, Van Chien, Tran, Chi, Nguyen Linh, Van Tuan, Nguyen, Van Sung, Tran, Ai Nhung, Nguyen Thi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8696980/
https://www.ncbi.nlm.nih.gov/pubmed/35423771
http://dx.doi.org/10.1039/d1ra00441g

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8696980/
https://www.ncbi.nlm.nih.gov/pubmed/35423771
http://dx.doi.org/10.1039/d1ra00441g

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