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Synthesis and evaluation of 3′-[(18)F]fluorothymidine-5′-squaryl as a bioisostere of 3′-[(18)F]fluorothymidine-5′-monophosphate
The squaryl moiety has emerged as an important phosphate bioisostere with reportedly greater cell permeability. It has been used in the synthesis of several therapeutic drug molecules including nucleoside and nucleotide analogues but is yet to be evaluated in the context of positron emission tomogra...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Royal Society of Chemistry
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8696986/ https://www.ncbi.nlm.nih.gov/pubmed/35423725 http://dx.doi.org/10.1039/d1ra00205h |