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Synthesis and evaluation of 3′-[(18)F]fluorothymidine-5′-squaryl as a bioisostere of 3′-[(18)F]fluorothymidine-5′-monophosphate

The squaryl moiety has emerged as an important phosphate bioisostere with reportedly greater cell permeability. It has been used in the synthesis of several therapeutic drug molecules including nucleoside and nucleotide analogues but is yet to be evaluated in the context of positron emission tomogra...

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Detalles Bibliográficos
Autores principales:	Brickute, D., Beckley, A., Allott, L., Braga, M., Barnes, C., Thorley, K. J., Aboagye, E. O.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Royal Society of Chemistry 2021
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8696986/ https://www.ncbi.nlm.nih.gov/pubmed/35423725 http://dx.doi.org/10.1039/d1ra00205h

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