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Talin in mechanotransduction and mechanomemory at a glance

Talins are cytoskeletal linker proteins that consist of an N-terminal head domain, a flexible neck region and a C-terminal rod domain made of 13 helical bundles. The head domain binds integrin β-subunit cytoplasmic tails, which triggers integrin conformational activation to increase affinity for ext...

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Detalles Bibliográficos
Autores principales: Goult, Benjamin T., Brown, Nicholas H., Schwartz, Martin A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8697387/
https://www.ncbi.nlm.nih.gov/pubmed/34708856
http://dx.doi.org/10.1242/jcs.258749