Regioselective Pd-catalyzed α-alkylation of furans using alkyl iodides

Herein, direct alkylation of the C–H bond at the α-position of furans catalyzed by palladium catalyst is reported. This protocol targets α-alkylfurans, achieving moderate to good yields under very practical reaction conditions. With a broad scope of substrates and good functional group tolerance, th...

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Detalles Bibliográficos
Autores principales: Yuan, Jiaqi, Zhang, Xiaofei, Yang, Chunhao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8697702/
https://www.ncbi.nlm.nih.gov/pubmed/35423913
http://dx.doi.org/10.1039/d1ra01522b
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author Yuan, Jiaqi
Zhang, Xiaofei
Yang, Chunhao
author_facet Yuan, Jiaqi
Zhang, Xiaofei
Yang, Chunhao
author_sort Yuan, Jiaqi
collection PubMed
description Herein, direct alkylation of the C–H bond at the α-position of furans catalyzed by palladium catalyst is reported. This protocol targets α-alkylfurans, achieving moderate to good yields under very practical reaction conditions. With a broad scope of substrates and good functional group tolerance, this method will has promising utility in medicinal chemistry.
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spelling pubmed-86977022022-04-13 Regioselective Pd-catalyzed α-alkylation of furans using alkyl iodides Yuan, Jiaqi Zhang, Xiaofei Yang, Chunhao RSC Adv Chemistry Herein, direct alkylation of the C–H bond at the α-position of furans catalyzed by palladium catalyst is reported. This protocol targets α-alkylfurans, achieving moderate to good yields under very practical reaction conditions. With a broad scope of substrates and good functional group tolerance, this method will has promising utility in medicinal chemistry. The Royal Society of Chemistry 2021-04-14 /pmc/articles/PMC8697702/ /pubmed/35423913 http://dx.doi.org/10.1039/d1ra01522b Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Yuan, Jiaqi
Zhang, Xiaofei
Yang, Chunhao
Regioselective Pd-catalyzed α-alkylation of furans using alkyl iodides
title Regioselective Pd-catalyzed α-alkylation of furans using alkyl iodides
title_full Regioselective Pd-catalyzed α-alkylation of furans using alkyl iodides
title_fullStr Regioselective Pd-catalyzed α-alkylation of furans using alkyl iodides
title_full_unstemmed Regioselective Pd-catalyzed α-alkylation of furans using alkyl iodides
title_short Regioselective Pd-catalyzed α-alkylation of furans using alkyl iodides
title_sort regioselective pd-catalyzed α-alkylation of furans using alkyl iodides
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8697702/
https://www.ncbi.nlm.nih.gov/pubmed/35423913
http://dx.doi.org/10.1039/d1ra01522b
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AT zhangxiaofei regioselectivepdcatalyzedaalkylationoffuransusingalkyliodides
AT yangchunhao regioselectivepdcatalyzedaalkylationoffuransusingalkyliodides

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