The effect on ion channel of different protonation states of E90 in channelrhodopsin-2: a molecular dynamics simulation

Channelrhodopsin-2 (ChR2) is a cationic channel protein that has been extensively studied in optogenetics. The ion channel is opened via a series of proton transfers and H-bond changes during the photocycle but the detailed mechanism is still unknown. Molecular dynamics (MD) simulations with enhance...

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Detalles Bibliográficos
Autores principales: Cheng, Jie, Zhang, Wenying, Zhou, Shuangyan, Ran, Xu, Shang, Yiwen, Lo, Glenn V., Dou, Yusheng, Yuan, Shuai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8697799/
https://www.ncbi.nlm.nih.gov/pubmed/35424009
http://dx.doi.org/10.1039/d1ra01879e

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8697799/
https://www.ncbi.nlm.nih.gov/pubmed/35424009
http://dx.doi.org/10.1039/d1ra01879e

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