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The effect on ion channel of different protonation states of E90 in channelrhodopsin-2: a molecular dynamics simulation
Channelrhodopsin-2 (ChR2) is a cationic channel protein that has been extensively studied in optogenetics. The ion channel is opened via a series of proton transfers and H-bond changes during the photocycle but the detailed mechanism is still unknown. Molecular dynamics (MD) simulations with enhance...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Royal Society of Chemistry
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8697799/ https://www.ncbi.nlm.nih.gov/pubmed/35424009 http://dx.doi.org/10.1039/d1ra01879e |