Site‐Specific Phosphorylation of Huntingtin Exon 1 Recombinant Proteins Enabled by the Discovery of Novel Kinases

Post‐translational modifications (PTMs) within the first 17 amino acids (Nt17) of exon 1 of the Huntingtin protein (Httex1) play important roles in modulating its cellular properties and functions in health and disease. In particular, phosphorylation of threonine and serine residues (T3, S13, and/or...

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Detalles Bibliográficos
Autores principales: Chiki, Anass, Ricci, Jonathan, Hegde, Ramanath, Abriata, Luciano A., Reif, Andreas, Boudeffa, Driss, Lashuel, Hilal A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Full Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8698011/
https://www.ncbi.nlm.nih.gov/pubmed/32805086
http://dx.doi.org/10.1002/cbic.202000508

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8698011/
https://www.ncbi.nlm.nih.gov/pubmed/32805086
http://dx.doi.org/10.1002/cbic.202000508

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