Cargando…

Site‐Specific Phosphorylation of Huntingtin Exon 1 Recombinant Proteins Enabled by the Discovery of Novel Kinases

Post‐translational modifications (PTMs) within the first 17 amino acids (Nt17) of exon 1 of the Huntingtin protein (Httex1) play important roles in modulating its cellular properties and functions in health and disease. In particular, phosphorylation of threonine and serine residues (T3, S13, and/or...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chiki, Anass, Ricci, Jonathan, Hegde, Ramanath, Abriata, Luciano A., Reif, Andreas, Boudeffa, Driss, Lashuel, Hilal A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2020
Materias:	Full Papers
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8698011/ https://www.ncbi.nlm.nih.gov/pubmed/32805086 http://dx.doi.org/10.1002/cbic.202000508

Ejemplares similares

Generation of Native, Untagged Huntingtin Exon1 Monomer and Fibrils Using a SUMO Fusion Strategy
por: Reif, Andreas, et al.
Publicado: (2018)

Investigating Crosstalk Among PTMs Provides Novel Insight Into the Structural Basis Underlying the Differential Effects of Nt17 PTMs on Mutant Httex1 Aggregation
por: Chiki, Anass, et al.
Publicado: (2021)

TBK1 phosphorylates mutant Huntingtin and suppresses its aggregation and toxicity in Huntington's disease models
por: Hegde, Ramanath Narayana, et al.
Publicado: (2020)

N-terminal Huntingtin (Htt) phosphorylation is a molecular switch regulating Htt aggregation, helical conformation, internalization, and nuclear targeting
por: DeGuire, Sean M., et al.
Publicado: (2018)

Phosphorylation of huntingtin at residue T3 is decreased in Huntington’s disease and modulates mutant huntingtin protein conformation
por: Cariulo, Cristina, et al.
Publicado: (2017)

Phosphorylation of the overlooked tyrosine 310 regulates the structure, aggregation, and microtubule- and lipid-binding properties of Tau
por: Ait-Bouziad, Nadine, et al.
Publicado: (2020)

Monomeric Huntingtin Exon 1 Has Similar Overall Structural Features for Wild-Type and Pathological Polyglutamine Lengths
por: Warner, John B., et al.
Publicado: (2017)

A simple, versatile and robust centrifugation‐based filtration protocol for the isolation and quantification of α‐synuclein monomers, oligomers and fibrils: Towards improving experimental reproducibility in α‐synuclein research
por: Kumar, Senthil T., et al.
Publicado: (2020)

Discovery of Novel Isoforms of Huntingtin Reveals a New Hominid-Specific Exon
por: Ruzo, Albert, et al.
Publicado: (2015)

Revisiting the specificity and ability of phospho-S129 antibodies to capture alpha-synuclein biochemical and pathological diversity
por: Lashuel, Hilal A., et al.
Publicado: (2022)

Protein kinase R dependent phosphorylation of α-synuclein regulates its membrane binding and aggregation
por: Reimer, Lasse, et al.
Publicado: (2022)

Pharmacological characterization of mutant huntingtin aggregate-directed PET imaging tracer candidates
por: Herrmann, Frank, et al.
Publicado: (2021)

Emerging Therapies for Huntington’s Disease – Focus on N-Terminal Huntingtin and Huntingtin Exon 1
por: van der Bent, M Leontien, et al.
Publicado: (2022)

The Role of Post-translational Modifications on the Energy Landscape of Huntingtin N-Terminus
por: Yalinca, Havva, et al.
Publicado: (2019)

Huntingtin exon 1 deletion does not alter the subcellular distribution of huntingtin and gene transcription in mice
por: Zhao, Xianxian, et al.
Publicado: (2022)

Truncation of mutant huntingtin in knock-in mice demonstrates exon1 huntingtin is a key pathogenic form
por: Yang, Huiming, et al.
Publicado: (2020)

Bifunctional Anti-Huntingtin Proteasome-Directed Intrabodies Mediate Efficient Degradation of Mutant Huntingtin Exon 1 Protein Fragments
por: Butler, David C., et al.
Publicado: (2011)

Author Correction: Truncation of mutant huntingtin in knock-in mice demonstrates exon1 huntingtin is a key pathogenic form
por: Yang, Huiming, et al.
Publicado: (2020)

Polyglutamine Induced Misfolding of Huntingtin Exon1 is Modulated by the Flanking Sequences
por: Lakhani, Vinal V., et al.
Publicado: (2010)

Aggregation Behavior of Chemically Synthesized, Full-Length Huntingtin Exon1
por: Sahoo, Bankanidhi, et al.
Publicado: (2014)

Cdk5 phosphorylation of huntingtin reduces its cleavage by caspases: implications for mutant huntingtin toxicity
por: Luo, Shouqing, et al.
Publicado: (2005)

Nuclear and cytoplasmic huntingtin inclusions exhibit distinct biochemical composition, interactome and ultrastructural properties
por: Riguet, Nathan, et al.
Publicado: (2021)

Perturbation with Intrabodies Reveals That Calpain Cleavage Is Required for Degradation of Huntingtin Exon 1
por: Southwell, Amber L., et al.
Publicado: (2011)

IKK phosphorylates Huntingtin and targets it for degradation by the proteasome and lysosome
por: Thompson, Leslie Michels, et al.
Publicado: (2009)

Remembering John Q Trojanowski, in his own words: A life dedicated to discovering building blocks and using them to build bridges of knowledge, collaboration, and discovery
por: Lashuel, Hilal A.
Publicado: (2022)

α-Synuclein and huntingtin exon 1 amyloid fibrils bind laterally to the cellular membrane
por: Monsellier, Elodie, et al.
Publicado: (2016)

A Liquid to Solid Phase Transition Underlying Pathological Huntingtin Exon1 Aggregation
por: Peskett, Thomas R., et al.
Publicado: (2018)

Phosphorylation of Mutant Huntingtin at Serine 116 Modulates Neuronal Toxicity
por: Watkin, Erin E., et al.
Publicado: (2014)

Cholesterol impacts the formation of huntingtin/lipid complexes and subsequent aggregation
por: Stonebraker, Alyssa R., et al.
Publicado: (2023)

Correlative light and electron microscopy suggests that mutant huntingtin dysregulates the endolysosomal pathway in presymptomatic Huntington’s disease
por: Zhou, Ya, et al.
Publicado: (2021)

Polyglutamine disruption of the huntingtin exon1 N-terminus triggers a complex aggregation mechanism
por: Thakur, Ashwani K., et al.
Publicado: (2009)

Cellular Inclusion Bodies of Mutant Huntingtin Exon 1 Obscure Small Fibrillar Aggregate Species
por: Sahl, Steffen J., et al.
Publicado: (2012)

Folding Landscape of Mutant Huntingtin Exon1: Diffusible Multimers, Oligomers and Fibrils, and No Detectable Monomer
por: Sahoo, Bankanidhi, et al.
Publicado: (2016)

Quantitative NMR analysis of the kinetics of prenucleation oligomerization and aggregation of pathogenic huntingtin exon-1 protein
por: Ceccon, Alberto, et al.
Publicado: (2022)

Integrative determination of the atomic structure of mutant huntingtin exon 1 fibrils from Huntington’s disease
por: Helabad, Mahdi Bagherpoor, et al.
Publicado: (2023)

Polyglutamine expansion affects huntingtin conformation in multiple Huntington’s disease models
por: Daldin, Manuel, et al.
Publicado: (2017)

Meso scale discovery-based assays for the detection of aggregated huntingtin
por: Reindl, Wolfgang, et al.
Publicado: (2019)

Presynaptic APP levels and synaptic homeostasis are regulated by Akt phosphorylation of huntingtin
por: Bruyère, Julie, et al.
Publicado: (2020)

Extent of N-terminus exposure of monomeric alpha-synuclein determines its aggregation propensity
por: Stephens, Amberley D., et al.
Publicado: (2020)

MicroExonator enables systematic discovery and quantification of microexons across mouse embryonic development
por: Parada, Guillermo E., et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_01iidqme33o8s8ks49frkujpaa