Alanine-scanning mutagenesis of protein mannosyl-transferase from Streptomyces coelicolor reveals strong activity-stability correlation

In Actinobacteria , protein O-mannosyl transferase (Pmt)-mediated protein O-glycosylation has an important role in cell envelope physiology. In S. coelicolor, defective Pmt leads to increased susceptibility to cell wall-targeting antibiotics, including vancomycin and β-lactams, and resistance to pha...

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Detalles Bibliográficos
Autores principales: Holman, Nathaniel D. M., Wilkinson, Anthony J., Smith, Margaret C. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Microbiology Society 2021
Materias:
Microbial Physiology, Biochemistry and Metabolism
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8698208/
https://www.ncbi.nlm.nih.gov/pubmed/34676818
http://dx.doi.org/10.1099/mic.0.001103

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8698208/
https://www.ncbi.nlm.nih.gov/pubmed/34676818
http://dx.doi.org/10.1099/mic.0.001103

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