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Alanine-scanning mutagenesis of protein mannosyl-transferase from Streptomyces coelicolor reveals strong activity-stability correlation

In Actinobacteria , protein O-mannosyl transferase (Pmt)-mediated protein O-glycosylation has an important role in cell envelope physiology. In S. coelicolor, defective Pmt leads to increased susceptibility to cell wall-targeting antibiotics, including vancomycin and β-lactams, and resistance to pha...

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Detalles Bibliográficos
Autores principales:	Holman, Nathaniel D. M., Wilkinson, Anthony J., Smith, Margaret C. M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Microbiology Society 2021
Materias:	Microbial Physiology, Biochemistry and Metabolism
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8698208/ https://www.ncbi.nlm.nih.gov/pubmed/34676818 http://dx.doi.org/10.1099/mic.0.001103

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