Predicting the Effects of Carbapenem/Carbapenemase Inhibitor Combinations against KPC-Producing Klebsiella pneumoniae in Time-Kill Experiments: Alternative versus Traditional Approaches to MIC Determination

Traditionally, the antibacterial activity of β-lactam antibiotics in the presence of β-lactamase inhibitors is determined at the fixed inhibitor concentration. This traditional approach does not consider the ratio of antibiotic-to-inhibitor concentrations achieved in humans. To explore whether an al...

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Detalles Bibliográficos
Autores principales: Filimonova, Alla V., Golikova, Maria V., Strukova, Elena N., Portnoy, Yury A., Kuznetsova, Anastasiya A., Zinner, Stephen H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8698301/
https://www.ncbi.nlm.nih.gov/pubmed/34943731
http://dx.doi.org/10.3390/antibiotics10121520

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8698301/
https://www.ncbi.nlm.nih.gov/pubmed/34943731
http://dx.doi.org/10.3390/antibiotics10121520

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