Cargando…

8-Hydroxydaidzein Downregulates JAK/STAT, MMP, Oxidative Phosphorylation, and PI3K/AKT Pathways in K562 Cells

A metabolite isolated from fermented soybean, 8-hydroxydaidzein (8-OHD, 7,8,4′-trihydroxyisoflavone, NSC-678112), is widely used in ethnopharmacological research due to its anti-proliferative and anti-inflammatory effects. We reported previously that 8-OHD provoked reactive oxygen species (ROS) over...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wu, Pei-Shan, Wang, Chih-Yang, Chen, Pin-Shern, Hung, Jui-Hsiang, Yen, Jui-Hung, Wu, Ming-Jiuan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8698423/ https://www.ncbi.nlm.nih.gov/pubmed/34944720 http://dx.doi.org/10.3390/biomedicines9121907

Ejemplares similares

8-Hydroxydaidzein, an Isoflavone from Fermented Soybean, Induces Autophagy, Apoptosis, Differentiation, and Degradation of Oncoprotein BCR-ABL in K562 Cells
por: Wu, Pei-Shan, et al.
Publicado: (2020)

8-Hydroxydaidzein Induces Apoptosis and Inhibits AML-Associated Gene Expression in U-937 Cells: Potential Phytochemical for AML Treatment
por: Wu, Pei-Shan, et al.
Publicado: (2023)

Thymoquinone Induces Downregulation of BCR-ABL/JAK/STAT Pathway and Apoptosis in K562 Leukemia Cells
por: Al-Rawashde, Futoon Abedrabbu, et al.
Publicado: (2021)

Sinomenine Inhibits Migration and Invasion of Human Lung Cancer Cell through Downregulating Expression of miR-21 and MMPs
por: Shen, Kun-Hung, et al.
Publicado: (2020)

Thymoquinone Inhibits JAK/STAT and PI3K/Akt/ mTOR Signaling Pathways in MV4-11 and K562 Myeloid Leukemia Cells
por: Al-Rawashde, Futoon Abedrabbu, et al.
Publicado: (2022)

The Flavagline Compound 1-(2-(dimethylamino)acetyl)-Rocaglaol Induces Apoptosis in K562 Cells by Regulating the PI3K/Akt/mTOR, JAK2/STAT3, and MAPK Pathways
por: Yang, Xinmei, et al.
Publicado: (2022)

Nobiletin Promotes Megakaryocytic Differentiation through the MAPK/ERK-Dependent EGR1 Expression and Exerts Anti-Leukemic Effects in Human Chronic Myeloid Leukemia (CML) K562 Cells
por: Yen, Jui-Hung, et al.
Publicado: (2020)

IL-6/JAK/STAT3介导苦参碱对K562细胞的增殖抑制作用
Publicado: (2015)

Thymoquinone Enhances Apoptosis of K562 Chronic Myeloid Leukemia Cells through Hypomethylation of SHP-1 and Inhibition of JAK/STAT Signaling Pathway
por: Al-Rawashde, Futoon Abedrabbu, et al.
Publicado: (2023)

Isolation, Bioactivity, and Production of ortho-Hydroxydaidzein and ortho-Hydroxygenistein
por: Chang, Te-Sheng
Publicado: (2014)

Ursolic acid-mediated apoptosis of K562 cells involves Stat5/Akt pathway inhibition through the induction of Gfi-1
por: Lin, Ze, et al.
Publicado: (2016)

Stat5 Exerts Distinct, Vital Functions in the Cytoplasm and Nucleus of Bcr-Abl(+) K562 and Jak2(V617F)(+) HEL Leukemia Cells
por: Weber, Axel, et al.
Publicado: (2015)

In Vitro Antileukemia Activity of ZSTK474 on K562 and Multidrug Resistant K562/A02 Cells
por: Zhou, Qianxiang, et al.
Publicado: (2016)

miRNA143 Induces K562 Cell Apoptosis Through Downregulating BCR-ABL
por: Liang, Bing, et al.
Publicado: (2016)

The Neuroprotective Effects of Flavonoid Fisetin against Corticosterone-Induced Cell Death through Modulation of ERK, p38, and PI3K/Akt/FOXO3a-Dependent Pathways in PC12 Cells
por: Chang, Pei-Rong, et al.
Publicado: (2023)

Apoptosis Induced by Tanshinone IIA and Cryptotanshinone Is Mediated by Distinct JAK/STAT3/5 and SHP1/2 Signaling in Chronic Myeloid Leukemia K562 Cells
por: Jung, Ji Hoon, et al.
Publicado: (2013)

Ampelopsin Inhibits Cell Proliferation and Induces Apoptosis in HL60 and K562 Leukemia Cells by Downregulating AKT and NF-κB Signaling Pathways
por: Han, Jang Mi, et al.
Publicado: (2021)

Knockdown of ZNF268, which Is Transcriptionally Downregulated by GATA-1, Promotes Proliferation of K562 Cells
por: Zeng, Yan, et al.
Publicado: (2012)

Corrigendum to “Apoptosis Induced by Tanshinone IIA and Cryptotanshinone Is Mediated by Distinct JAK/STAT3/5 and SHP1/2 Signaling in Chronic Myeloid Leukemia K562 Cells”
por: Jung, Ji Hoon, et al.
Publicado: (2018)

Rapamycin enhanced the antitumor effects of doxorubicin in myelogenous leukemia K562 cells by downregulating the mTOR/p70S6K pathway
por: Li, Jie, et al.
Publicado: (2019)

Characterization of an Etoposide‐resistant Human K562 Cell Line, K/eto
por: Sugawara, Isamu, et al.
Publicado: (1991)

Evaluation of Depigmenting Activity by 8-Hydroxydaidzein in Mouse B16 Melanoma Cells and Human Volunteers
por: Tai, Sorgan Shou-Ku, et al.
Publicado: (2009)

Synergistic effects of thalidomide and cisplatin are mediated via the PI3K/AKT and JAK1/STAT3 signaling pathways in cervical cancer
por: Liu, Cairu, et al.
Publicado: (2022)

The Jak/Stat Signaling Pathway Is Downregulated at Febrile Temperatures
por: Nespital, Tobias, et al.
Publicado: (2012)

Proteomic Analysis of Quercetin-Treated K562 Cells
por: Brisdelli, Fabrizia, et al.
Publicado: (2019)

Induction of Cellular Senescence by Doxorubicin Is Associated with Upregulated miR-375 and Induction of Autophagy in K562 Cells
por: Yang, Ming-Yu, et al.
Publicado: (2012)

Piperlongumine reverses doxorubicin resistance through the PI3K/Akt signaling pathway in K562/A02 human leukemia cells
por: KANG, QINGWEI, et al.
Publicado: (2015)

PI3K-AKT, JAK2-STAT3 pathways and cell–cell contact regulate maspin subcellular localization
por: Longhi, M. T., et al.
Publicado: (2021)

Antrodia cinnamomea boosts the anti-tumor activity of sorafenib in xenograft models of human hepatocellular carcinoma
por: Wu, Wei-De, et al.
Publicado: (2018)

JAK–STAT inhibition impairs K‐RAS‐driven lung adenocarcinoma progression
por: Mohrherr, Julian, et al.
Publicado: (2019)

Downregulation of MDR1 Gene by Cepharanthine Hydrochloride Is Related to the Activation of c-Jun/JNK in K562/ADR Cells
por: Han, Li, et al.
Publicado: (2014)

Voltage-Gated K(+) Channel, K(v)3.3 Is Involved in Hemin-Induced K562 Differentiation
por: Song, Min Seok, et al.
Publicado: (2016)

Pyrimidine-5-carbonitrile based potential anticancer agents as apoptosis inducers through PI3K/AKT axis inhibition in leukaemia K562
por: El-Dydamony, Nehad M., et al.
Publicado: (2022)

Butyrate augments interferon-α-induced S phase accumulation and persistent tyrosine phosphorylation of cdc2 in K562 cells
por: Miyachi, T, et al.
Publicado: (1999)

Cbl-mediated K63-linked ubiquitination of JAK2 enhances JAK2 phosphorylation and signal transduction
por: Liu, Chun-Shan, et al.
Publicado: (2017)

Establishment and molecular characterization of decitabine‐resistant K562 cells
por: Wen, Xiang‐Mei, et al.
Publicado: (2019)

The Mechanism of Bufalin-Induced Apoptosis of K562/A02
por: Xie, Ying, et al.
Publicado: (2019)

Antiviral Effectivity of Favipiravir Against Peste Des Petits Ruminants Virus Is Mediated by the JAK/STAT and PI3K/AKT Pathways
por: Zhang, Weifeng, et al.
Publicado: (2021)

Rosmanol induces breast cancer cells apoptosis by regulating PI3K/AKT and STAT3/JAK2 signaling pathways
por: Jiang, Dongjun, et al.
Publicado: (2021)

Sinulariolide Inhibits Gastric Cancer Cell Migration and Invasion through Downregulation of the EMT Process and Suppression of FAK/PI3K/AKT/mTOR and MAPKs Signaling Pathways
por: Wu, Yu-Jen, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_jtnet8dnu845s3t6l1l4qvhrpc