N-Acetylcysteine Reverses the Mitochondrial Dysfunction Induced by Very Long-Chain Fatty Acids in Murine Oligodendrocyte Model of Adrenoleukodystrophy

The accumulation of saturated very long-chain fatty acids (VLCFA, ≥C22:0) due to peroxisomal impairment leads to oxidative stress and neurodegeneration in X-linked adrenoleukodystrophy (ALD). Among the neural supporting cells, myelin-producing oligodendrocytes are the most sensitive to the detriment...

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Detalles Bibliográficos
Autores principales: Zhou, Jie, Terluk, Marcia R., Orchard, Paul J., Cloyd, James C., Kartha, Reena V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8698433/
https://www.ncbi.nlm.nih.gov/pubmed/34944641
http://dx.doi.org/10.3390/biomedicines9121826

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8698433/
https://www.ncbi.nlm.nih.gov/pubmed/34944641
http://dx.doi.org/10.3390/biomedicines9121826

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