An Untargeted Lipidomic Analysis Reveals Depletion of Several Phospholipid Classes in Patients with Familial Hypercholesterolemia on Treatment with Evolocumab

Rationale: Familial hypercholesterolemia (FH) is caused by mutations in genes involved in low-density lipoprotein cholesterol (LDL-C) metabolism, including those for pro-protein convertase subtilisin/kexin type 9 (PCSK-9). The effect of PCSK-9 inhibition on the plasma lipidome has been poorly explor...

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Detalles Bibliográficos
Autores principales: Anesi, Andrea, Di Minno, Alessandro, Calcaterra, Ilenia, Cavalca, Viviana, Tripaldella, Maria, Porro, Benedetta, Di Minno, Matteo Nicola Dario
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8698529/
https://www.ncbi.nlm.nih.gov/pubmed/34944757
http://dx.doi.org/10.3390/biomedicines9121941

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8698529/
https://www.ncbi.nlm.nih.gov/pubmed/34944757
http://dx.doi.org/10.3390/biomedicines9121941

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