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An Untargeted Lipidomic Analysis Reveals Depletion of Several Phospholipid Classes in Patients with Familial Hypercholesterolemia on Treatment with Evolocumab

Rationale: Familial hypercholesterolemia (FH) is caused by mutations in genes involved in low-density lipoprotein cholesterol (LDL-C) metabolism, including those for pro-protein convertase subtilisin/kexin type 9 (PCSK-9). The effect of PCSK-9 inhibition on the plasma lipidome has been poorly explor...

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Detalles Bibliográficos
Autores principales:	Anesi, Andrea, Di Minno, Alessandro, Calcaterra, Ilenia, Cavalca, Viviana, Tripaldella, Maria, Porro, Benedetta, Di Minno, Matteo Nicola Dario
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8698529/ https://www.ncbi.nlm.nih.gov/pubmed/34944757 http://dx.doi.org/10.3390/biomedicines9121941

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