Activation of PKCε-ALDH2 Axis Prevents 4-HNE-Induced Pain in Mice

Protein kinase Cε (PKCε) is highly expressed in nociceptor neurons and its activation has been reported as pro-nociceptive. Intriguingly, we previously demonstrated that activation of the mitochondrial PKCε substrate aldehyde dehydrogenase-2 (ALDH2) results in anti-nociceptive effects. ALDH2 is a ma...

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Detalles Bibliográficos
Autores principales: Martins, Bárbara B., Hösch, Natália G., Alcantara, Queren A., Budas, Grant R., Chen, Che-Hong, Mochly-Rosen, Daria, Ferreira, Julio C. B., Zambelli, Vanessa O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8698646/
https://www.ncbi.nlm.nih.gov/pubmed/34944441
http://dx.doi.org/10.3390/biom11121798

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8698646/
https://www.ncbi.nlm.nih.gov/pubmed/34944441
http://dx.doi.org/10.3390/biom11121798

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