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Pharmacological Inhibition of NOX4 Improves Mitochondrial Function and Survival in Human Beta-Cells

Previous studies have reported beneficial effects of NADPH oxidase 4 (NOX4) inhibition on beta-cell survival in vitro and in vivo. The mechanisms by which NOX4 inhibition protects insulin producing cells are, however, not known. The aim of the present study was to investigate the effects of a pharma...

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Detalles Bibliográficos
Autores principales: Elksnis, Andris, Cen, Jing, Wikström, Per, Carlsson, Per-Ola, Welsh, Nils
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8698703/
https://www.ncbi.nlm.nih.gov/pubmed/34944680
http://dx.doi.org/10.3390/biomedicines9121865