Triple Isozyme Lactic Acid Dehydrogenase Inhibition in Fully Viable MDA-MB-231 Cells Induces Cytostatic Effects That Are Not Reversed by Exogenous Lactic Acid

A number of aggressive human malignant tumors are characterized by an intensified glycolytic rate, over-expression of lactic acid dehydrogenase A (LDHA), and subsequent lactate accumulation, all of which contribute toward an acidic peri-cellular immunosuppressive tumor microenvironment (TME). While...

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Detalles Bibliográficos
Autores principales: Mazzio, Elizabeth, Mack, Nzinga, Badisa, Ramesh B., Soliman, Karam F. A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8698706/
https://www.ncbi.nlm.nih.gov/pubmed/34944395
http://dx.doi.org/10.3390/biom11121751

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8698706/
https://www.ncbi.nlm.nih.gov/pubmed/34944395
http://dx.doi.org/10.3390/biom11121751

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