Butyrate Protects against Diet-Induced NASH and Liver Fibrosis and Suppresses Specific Non-Canonical TGF-β Signaling Pathways in Human Hepatic Stellate Cells

In obesity-associated non-alcoholic steatohepatitis (NASH), persistent hepatocellular damage and inflammation are key drivers of fibrosis, which is the main determinant of NASH-associated mortality. The short-chain fatty acid butyrate can exert metabolic improvements and anti-inflammatory activities...

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Detalles Bibliográficos
Autores principales: Gart, Eveline, van Duyvenvoorde, Wim, Toet, Karin, Caspers, Martien P. M., Verschuren, Lars, Nielsen, Mette Juul, Leeming, Diana Julie, Souto Lima, Everton, Menke, Aswin, Hanemaaijer, Roeland, Keijer, Jaap, Salic, Kanita, Kleemann, Robert, Morrison, Martine C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8698820/
https://www.ncbi.nlm.nih.gov/pubmed/34944770
http://dx.doi.org/10.3390/biomedicines9121954

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8698820/
https://www.ncbi.nlm.nih.gov/pubmed/34944770
http://dx.doi.org/10.3390/biomedicines9121954

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