C3d Elicits Neutrophil Degranulation and Decreases Endothelial Cell Migration, with Implications for Patients with Alpha-1 Antitrypsin Deficiency

Alpha-1 antitrypsin (AAT) deficiency (AATD) is characterized by increased risk for emphysema, chronic obstructive pulmonary disease (COPD), vasculitis, and wound-healing impairment. Neutrophils play a central role in the pathogenesis of AATD. Dysregulated complement activation in AATD results in inc...

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Detalles Bibliográficos
Autores principales: Fee, Laura T., Gogoi, Debananda, O’Brien, Michael E., McHugh, Emer, Casey, Michelle, Gough, Ciara, Murphy, Mark, Hopkins, Ann M., Carroll, Tomás P., McElvaney, Noel G., Reeves, Emer P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8698851/
https://www.ncbi.nlm.nih.gov/pubmed/34944741
http://dx.doi.org/10.3390/biomedicines9121925

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8698851/
https://www.ncbi.nlm.nih.gov/pubmed/34944741
http://dx.doi.org/10.3390/biomedicines9121925

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