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Long-Term Pharmacological Inhibition of the Activity of All NOS Isoforms Rather Than Genetic Knock-Out of Endothelial NOS Leads to Impaired Spatial Learning and Memory in C57BL/6 Mice

Increasing epidemiological and experimental evidence points to a link between arterial stiffness and rapid cognitive decline. However, the underlying mechanism linking the two diseases is still unknown. The importance of nitric oxide synthases in both diseases is well-defined. In this study, we intr...

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Detalles Bibliográficos
Autores principales: Hendrickx, Jhana O., De Moudt, Sofie, Calus, Elke, De Deyn, Peter Paul, Van Dam, Debby, De Meyer, Guido R. Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8698888/
https://www.ncbi.nlm.nih.gov/pubmed/34944725
http://dx.doi.org/10.3390/biomedicines9121905