Which Properties Allow Ligands to Open and Bind to the Transient Binding Pocket of Human Aldose Reductase?

The transient specificity pocket of aldose reductase only opens in response to specific ligands. This pocket may offer an advantage for the development of novel, more selective ligands for proteins with similar topology that lack such an adaptive pocket. Our aim was to elucidate which properties all...

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Detalles Bibliográficos
Autores principales: Sandner, Anna, Ngo, Khang, Sager, Christoph P., Scheer, Frithjof, Daude, Michael, Diederich, Wibke E., Heine, Andreas, Klebe, Gerhard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8699021/
https://www.ncbi.nlm.nih.gov/pubmed/34944481
http://dx.doi.org/10.3390/biom11121837

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8699021/
https://www.ncbi.nlm.nih.gov/pubmed/34944481
http://dx.doi.org/10.3390/biom11121837

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