Increased Replication Stress Determines ATR Inhibitor Sensitivity in Neuroblastoma Cells

SIMPLE SUMMARY: Neuroblastoma is a childhood cancer with poor survival and new therapies are urgently needed, especially for high-risk disease. Here, we demonstrate that novel drugs targeting a protein called ATR can specifically kill a type of high-risk neuroblastoma associated with MYCN expression...

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Detalles Bibliográficos
Autores principales: King, David, Southgate, Harriet E. D., Roetschke, Saskia, Gravells, Polly, Fields, Leona, Watson, Jessica B., Chen, Lindi, Chapman, Devon, Harrison, Daniel, Yeomanson, Daniel, Curtin, Nicola J., Tweddle, Deborah A., Bryant, Helen E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8699051/
https://www.ncbi.nlm.nih.gov/pubmed/34944835
http://dx.doi.org/10.3390/cancers13246215

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8699051/
https://www.ncbi.nlm.nih.gov/pubmed/34944835
http://dx.doi.org/10.3390/cancers13246215

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