Influence of Estrogen Treatment on ESR1(+) and ESR1(−) Cells in ER(+) Breast Cancer: Insights from Single-Cell Analysis of Patient-Derived Xenograft Models

SIMPLE SUMMARY: The benefit of endocrine therapy is normally observed for cancers with 10% or more of cells positive for ER expression. We compared the gene expression profiles in both ESR1(+) and ESR1(–) cells in ER(+) tumors following estrogen treatment. Our single-cell RNA sequencing analysis of...

Descripción completa

Detalles Bibliográficos
Autores principales: Mori, Hitomi, Saeki, Kohei, Chang, Gregory, Wang, Jinhui, Wu, Xiwei, Hsu, Pei-Yin, Kanaya, Noriko, Wang, Xiaoqiang, Somlo, George, Nakamura, Masafumi, Bild, Andrea, Chen, Shiuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8699443/
https://www.ncbi.nlm.nih.gov/pubmed/34944995
http://dx.doi.org/10.3390/cancers13246375

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8699443/
https://www.ncbi.nlm.nih.gov/pubmed/34944995
http://dx.doi.org/10.3390/cancers13246375

Ejemplares similares