Phase I Trial of Oral Yeast-Derived β-Glucan to Enhance Anti-GD2 Immunotherapy of Resistant High-Risk Neuroblastoma

SIMPLE SUMMARY: Beta glucans, complex polysaccharides, can prime leukocyte dectin-1 and CR3-receptors and enhance anti-tumor cytotoxicity of monoclonal antibodies. In a phase I study (clinicaltrials.gov NCT00492167), we treated patients with intravenous 3F8 (fixed dose of 10 mg/m(2)/day × 10 days) a...

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Detalles Bibliográficos
Autores principales: Cardenas, Fiorella Iglesias, Mauguen, Audrey, Cheung, Irene Y., Kramer, Kim, Kushner, Brian H., Ragupathi, Govind, Cheung, Nai-Kong V., Modak, Shakeel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8699451/
https://www.ncbi.nlm.nih.gov/pubmed/34944886
http://dx.doi.org/10.3390/cancers13246265

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8699451/
https://www.ncbi.nlm.nih.gov/pubmed/34944886
http://dx.doi.org/10.3390/cancers13246265

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