Efficacy and Synergy of Small Molecule Inhibitors Targeting FLT3-ITD(+) Acute Myeloid Leukemia

SIMPLE SUMMARY: FLT3-ITD mutations belong to the most frequent yet most detrimental genetic alterations in AML. Next-generation FLT3 inhibitors are potent therapeutics and often effective in AML patients carrying the FLT3-ITD driver kinase. However, AML cells are particularly quick in acquiring resi...

Descripción completa

Detalles Bibliográficos
Autores principales: Bregante, Javier, Schönbichler, Anna, Pölöske, Daniel, Degenfeld-Schonburg, Lina, Monzó Contreras, Garazi, Hadzijusufovic, Emir, de Araujo, Elvin D., Valent, Peter, Moriggl, Richard, Orlova, Anna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8699584/
https://www.ncbi.nlm.nih.gov/pubmed/34944800
http://dx.doi.org/10.3390/cancers13246181

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8699584/
https://www.ncbi.nlm.nih.gov/pubmed/34944800
http://dx.doi.org/10.3390/cancers13246181

Ejemplares similares