Parkin beyond Parkinson’s Disease—A Functional Meaning of Parkin Downregulation in TDP-43 Proteinopathies

Parkin and PINK1 are key regulators of mitophagy, an autophagic pathway for selective elimination of dysfunctional mitochondria. To this date, parkin depletion has been associated with recessive early onset Parkinson’s disease (PD) caused by loss-of-function mutations in the PARK2 gene, while, in sp...

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Detalles Bibliográficos
Autores principales: Gaweda-Walerych, Katarzyna, Sitek, Emilia Jadwiga, Narożańska, Ewa, Buratti, Emanuele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8699658/
https://www.ncbi.nlm.nih.gov/pubmed/34943897
http://dx.doi.org/10.3390/cells10123389

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8699658/
https://www.ncbi.nlm.nih.gov/pubmed/34943897
http://dx.doi.org/10.3390/cells10123389

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