A Transgenic Model Reveals the Role of Klotho in Pancreatic Cancer Development and Paves the Way for New Klotho-Based Therapy

SIMPLE SUMMARY: We aimed to study the role of the anti-aging protein klotho and its secreted isoform, sKL, in pancreatic cancer. Three in vivo models, including a novel genetic mouse model and bioinformatics analyses, indicated klotho as a tumor suppressor in pancreatic ductal adenocarcinoma, and un...

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Detalles Bibliográficos
Autores principales: Arbel Rubinstein, Tammi, Reuveni, Inbal, Hesin, Arkadi, Klein-Goldberg, Anat, Olauson, Hannes, Larsson, Tobias E., Abraham, Carmela R., Zeldich, Ella, Bosch, Assumpció, Chillón, Miguel, Hollander, Kenneth Samuel, Shabtay-Orbach, Ayelet, Vainer, Gilad W., Wolf, Ido, Rubinek, Tami
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8699737/
https://www.ncbi.nlm.nih.gov/pubmed/34944918
http://dx.doi.org/10.3390/cancers13246297

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8699737/
https://www.ncbi.nlm.nih.gov/pubmed/34944918
http://dx.doi.org/10.3390/cancers13246297

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