Tolerance Induced by Antigen-Loaded PLG Nanoparticles Affects the Phenotype and Trafficking of Transgenic CD4(+) and CD8(+) T Cells

We have shown that PLG nanoparticles loaded with peptide antigen can reduce disease in animal models of autoimmunity and in a phase 1/2a clinical trial in celiac patients. Clarifying the mechanisms by which antigen-loaded nanoparticles establish tolerance is key to further adapting them to clinical...

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Detalles Bibliográficos
Autores principales: Neef, Tobias, Ifergan, Igal, Beddow, Sara, Penaloza-MacMaster, Pablo, Haskins, Kathryn, Shea, Lonnie D., Podojil, Joseph R., Miller, Stephen D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8699785/
https://www.ncbi.nlm.nih.gov/pubmed/34943952
http://dx.doi.org/10.3390/cells10123445

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8699785/
https://www.ncbi.nlm.nih.gov/pubmed/34943952
http://dx.doi.org/10.3390/cells10123445

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