Inhibition of β-catenin dependent WNT signalling upregulates the transcriptional repressor NR0B1 and downregulates markers of an A9 phenotype in human embryonic stem cell-derived dopaminergic neurons: Implications for Parkinson’s disease

In this study we investigate how β-catenin-dependent WNT signalling impacts midbrain dopaminergic neuron (mDA) specification. mDA cultures at day 65 of differentiation responded to 25 days of the tankyrase inhibitor XAV969 (XAV, 100nM) with reduced expression of markers of an A9 mDA phenotype (KCNJ6...

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Detalles Bibliográficos
Autores principales: Haynes, John M., Sibuea, Shanti M., Aguiar, Alita A., Li, Fangwei, Ho, Joan K., Pouton, Colin W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8700011/
https://www.ncbi.nlm.nih.gov/pubmed/34941945
http://dx.doi.org/10.1371/journal.pone.0261730

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8700011/
https://www.ncbi.nlm.nih.gov/pubmed/34941945
http://dx.doi.org/10.1371/journal.pone.0261730

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