Cargando…

Inhibition of β-catenin dependent WNT signalling upregulates the transcriptional repressor NR0B1 and downregulates markers of an A9 phenotype in human embryonic stem cell-derived dopaminergic neurons: Implications for Parkinson’s disease

In this study we investigate how β-catenin-dependent WNT signalling impacts midbrain dopaminergic neuron (mDA) specification. mDA cultures at day 65 of differentiation responded to 25 days of the tankyrase inhibitor XAV969 (XAV, 100nM) with reduced expression of markers of an A9 mDA phenotype (KCNJ6...

Descripción completa

Detalles Bibliográficos
Autores principales:	Haynes, John M., Sibuea, Shanti M., Aguiar, Alita A., Li, Fangwei, Ho, Joan K., Pouton, Colin W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8700011/ https://www.ncbi.nlm.nih.gov/pubmed/34941945 http://dx.doi.org/10.1371/journal.pone.0261730

Ejemplares similares

TGFβ3, dibutyryl cAMP and a notch inhibitor modulate phenotype late in stem cell-derived dopaminergic neuron maturation
por: Sibuea, Shanti, et al.
Publicado: (2023)

In Vitro Maturation of Dopaminergic Neurons Derived from Mouse Embryonic Stem Cells: Implications for Transplantation
por: Watmuff, Bradley, et al.
Publicado: (2012)

Wnt/β-catenin signaling promotes neurogenesis in the diencephalospinal dopaminergic system of embryonic zebrafish
por: Westphal, Markus, et al.
Publicado: (2022)

Atractylochromene Is a Repressor of Wnt/β-Catenin Signaling in Colon Cancer Cells
por: Shim, Ah-Ram, et al.
Publicado: (2015)

Vitamin D Is a Multilevel Repressor of Wnt/β-Catenin Signaling in Cancer Cells
por: Larriba, María Jesús, et al.
Publicado: (2013)

Downregulation of the Repressor Element 1-Silencing Transcription Factor (REST) Is Associated with Akt-mTOR and Wnt-β-Catenin Signaling in Prion Diseases Models
por: Song, Zhiqi, et al.
Publicado: (2017)

Downregulated Wnt/β-catenin signalling in the Down syndrome hippocampus
por: Granno, Simone, et al.
Publicado: (2019)

Loss of the transcriptional repressor Rev-erbα upregulates metabolism and proliferation in cultured mouse embryonic fibroblasts
por: Gillis, Sean P., et al.
Publicado: (2021)

miR-7 Controls the Dopaminergic/Oligodendroglial Fate through Wnt/β-catenin Signaling Regulation
por: Adusumilli, Lavanya, et al.
Publicado: (2020)

Wnt/beta-catenin signaling in embryonic stem cell converted tumor cells
por: Peng, Xinrong, et al.
Publicado: (2012)

Downregulated exosomal microRNA-148b-3p in cancer associated fibroblasts enhance chemosensitivity of bladder cancer cells by downregulating the Wnt/β-catenin pathway and upregulating PTEN
por: Shan, Guang, et al.
Publicado: (2021)

Inhibition of the Wnt palmitoyltransferase porcupine suppresses cell growth and downregulates the Wnt/β-catenin pathway in gastric cancer
por: MO, MIN-LI, et al.
Publicado: (2013)

Leptin promotes the growth of breast cancer by upregulating the Wnt/β-catenin pathway
por: Liang, Xi, et al.
Publicado: (2018)

A Dynamic WNT/β-CATENIN Signaling Environment Leads to WNT-Independent and WNT-Dependent Proliferation of Embryonic Intestinal Progenitor Cells
por: Chin, Alana M., et al.
Publicado: (2016)

Correction to: Downregulated exosomal microRNA-148b-3p in cancer associated fibroblasts enhance chemosensitivity of bladder cancer cells by downregulating the Wnt/β-catenin pathway and upregulating PTEN
por: Shan, Guang, et al.
Publicado: (2021)

The Wnt/β-catenin signaling pathway is involved in regulating feather growth of embryonic chicks
por: Xie, W.Y., et al.
Publicado: (2020)

Nr5a2 promotes tumor growth and metastasis of gastric cancer AGS cells by Wnt/beta-catenin signaling
por: Liu, Lei, et al.
Publicado: (2019)

Zeylenone represses the progress of human prostate cancer by downregulating the Wnt/β-catenin pathway
por: Zeng, Shaohua, et al.
Publicado: (2018)

GSTZ1‐1 downregulates Wnt/β‐catenin signalling in hepatocellular carcinoma cells
por: Lei, Chong, et al.
Publicado: (2019)

Lower Nr5a2 Level Downregulates the β-Catenin and TCF-4 Expression in Caerulein-Induced Pancreatic Inflammation
por: Sun, Ya Mei, et al.
Publicado: (2020)

Neuropilin-1 is upregulated by Wnt/β-catenin signaling and is important for mammary stem cells
por: Liu, Wei, et al.
Publicado: (2017)

Wnt/β-Catenin Signaling Pathway Governs a Full Program for Dopaminergic Neuron Survival, Neurorescue and Regeneration in the MPTP Mouse Model of Parkinson’s Disease
por: Marchetti, Bianca
Publicado: (2018)

Commentary: Ghrelin promotes midbrain neural stem cells differentiation to dopaminergic neurons through the Wnt/β-catenin pathway
por: Gayden, Jenesis D., et al.
Publicado: (2020)

Endogenous Wnt/β-Catenin Signaling Is Required for Cardiac Differentiation in Human Embryonic Stem Cells
por: Paige, Sharon L., et al.
Publicado: (2010)

CKD-581 Downregulates Wnt/β-Catenin Pathway by DACT3 Induction in Hematologic Malignancy
por: Kim, Soo Jin, et al.
Publicado: (2022)

Loss of endothelial glucocorticoid receptor promotes angiogenesis via upregulation of Wnt/β-catenin pathway
por: Liu, Bing, et al.
Publicado: (2021)

Genome-wide occupancy links Hoxa2 to Wnt–β-catenin signaling in mouse embryonic development
por: Donaldson, Ian J., et al.
Publicado: (2012)

Wnt6 influences the viability of mouse embryonic palatal mesenchymal cells via the β-catenin pathway
por: Jiang, Zheng, et al.
Publicado: (2017)

Wnt/β-catenin signaling pathway safeguards epigenetic stability and homeostasis of mouse embryonic stem cells
por: Theka, Ilda, et al.
Publicado: (2019)

Wnt/β-catenin Pathway-Mediated PPARδ Expression during Embryonic Development Differentiation and Disease
por: Sidrat, Tabinda, et al.
Publicado: (2021)

The Long Non-Coding HOTAIR Is Modulated by Cyclic Stretch and WNT/β-CATENIN in Human Aortic Valve Cells and Is a Novel Repressor of Calcification Genes
por: Carrion, Katrina, et al.
Publicado: (2014)

Targeting CDH17 Suppresses Tumor Progression in Gastric Cancer by Downregulating Wnt/β-Catenin Signaling
por: Qiu, Hai-bo, et al.
Publicado: (2013)

Downregulation of MMSET impairs breast cancer proliferation and metastasis through inhibiting Wnt/β-catenin signaling
por: Zhao, Xiaohui, et al.
Publicado: (2019)

Overexpression of CD300A inhibits progression of NSCLC through downregulating Wnt/β-catenin pathway
por: Tang, Ze, et al.
Publicado: (2018)

Effects of LDOC1 on colorectal cancer cells via downregulation of the Wnt/β-catenin signaling pathway
por: Jiang, Jiayi, et al.
Publicado: (2019)

Curcumin suppresses colorectal tumorigenesis via the Wnt/β-catenin signaling pathway by downregulating Axin2
por: Hao, Jiaxue, et al.
Publicado: (2021)

Inhibition of Dishevelled-2 suppresses the biological behavior of pancreatic cancer by downregulating Wnt/β-catenin signaling
por: Hu, Wei, et al.
Publicado: (2021)

OLFML2A Downregulation Inhibits Glioma Proliferation Through Suppression of Wnt/β-Catenin Signaling
por: Ma, Shize, et al.
Publicado: (2021)

Downregulation of TET1 Promotes Glioma Cell Proliferation and Invasion by Targeting Wnt/β-Catenin Pathway
por: Ji, Jianwen, et al.
Publicado: (2021)

Wnt3a upregulates brain-derived insulin by increasing NeuroD1 via Wnt/β-catenin signaling in the hypothalamus
por: Lee, Jaemeun, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_48c95gdpjsqbh7dskg2g24omlv