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Epitope profiling using computational structural modelling demonstrated on coronavirus-binding antibodies

Identifying the epitope of an antibody is a key step in understanding its function and its potential as a therapeutic. Sequence-based clonal clustering can identify antibodies with similar epitope complementarity, however, antibodies from markedly different lineages but with similar structures can e...

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Detalles Bibliográficos
Autores principales: Robinson, Sarah A., Raybould, Matthew I. J., Schneider, Constantin, Wong, Wing Ki, Marks, Claire, Deane, Charlotte M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8700021/
https://www.ncbi.nlm.nih.gov/pubmed/34898603
http://dx.doi.org/10.1371/journal.pcbi.1009675